Effect of different doses of parecoxib on perioperative cellular factors and the maintenance dose of propofol in patients with laparoscopic cervical cancer surgery / 中国生化药物杂志

ABSTRACT

Objective To analyse effect of different doses of parecoxib on perioperative cellular factors and the maintenance dose of propofol in patients with laparoscopic cervical cancer surgery.Methods Collected 60 patients who were diagnosed with cervical cancer in our hospital from June 2014 to June 2015.All patients underwent laparoscopic surgery,according to the injection of parecoxib different amount before induction of anesthesia divided into control group,low dose group and high dose group,20 cases in each group,respectively before anesthesia, postoperative, postoperative 12 h and postoperative 24 h, of all patients with serum IL-6, IL-12 and TNF-a level,intraoperative propofol maintenance dose,and postoperative analgesia were detected.ResuIts The levels of serum IL-6 and TNF-αin three groups showed thathigh dose group low dose group>control group (P<0.05).The maintenance dose of propofol in the three groups showed thathigh dose group dose group<control group (P <0.05).The postoperative VAS,RS score in the three groups showed thathigh dose groupdose group<control group (P<0.05).ConcIusions High dose of parecoxib can significantly reduce the blood serum IL-6, TNF-αlevel and increase the content of serum IL-12 in patient patients with laparoscopic cervical cancer surgery, and reduce intraoperative propofol dose,good analgesic effect.