Detection of YMDD mutations in hepatitis B virus and analysis of its clinical significance / 国际检验医学杂志
International Journal of Laboratory Medicine
; (12): 2197-2198,2201, 2015.
Article
in Zh
| WPRIM
| ID: wpr-602282
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WPRO
ABSTRACT
Objective To discuss YMDD mutation ,related factors and clinical significance in chronic hepatitis B patients ,provi‐ding the basis for clinical diagnosis and treatment .Methods YMDD mutations and DNA load of hepatitis B virus in 100 chronic hepatitis B patients were detected by real‐time fluorescence PCR .Results YMDD mutations of hepatitis B virus were found in 13 out of 100 patients(positive rate 13% ) .Including YIDD mutations in 7 ,YVDD mutations in 5 and YIDD/YVDD symbiotic mutation in 1 .In the 13 patients ,HBV DNA load and ALT level were at (1 .77 × 105 -1 × 108 )IU/mL and 18 .1-273 .5 U/L .Conclusion Do not find the detection rate of YMDD mutation in chronic hepatitis B patients is related with gender ,age ,HBeAg status ,HBV DNA load and ALT level ,the difference has no statistical significance (P>0 .05) .
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Index:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
International Journal of Laboratory Medicine
Year:
2015
Type:
Article