Ultrastructural impairment of islet microvascular endothelial cells in STZ-induced type 1 diabetic mice / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 1520-1524,1530, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-602379
ABSTRACT
AIM:
ToinvestigatetheultrastructuralchangesofisletmicrovascularendothelialcellsinSTZ-in-duced type 1 diabetic mice .METHODS:
BALB/c mice were randomly divided into diabetic group and control group .The expression of insulin and platelet-endothelial cell adhesion molecule-1 ( CD31) in islet microvessels was detected by immu-nohistochemical staining .The ultrastructural changes of islet βcells and islet microvessels were observed under transmis-sion electron microscope .RESULTS:
Compared with control group , the number of islet βcells, ratio of βcells/αcells, average number of secretory granules in βcells and insulin expression area per islet in diabetic group were significantly de-creased (P<0.01).Besides, diabetic group had fewer microvessels with lower expression of CD 31 (P<0.01).Mito-chondria in islet microvascular endothelial cells and pericytes in diabetic group were swelling .The basement membrane of islet microvessels became thicker in diabetic group ( P<0.01 ) .CONCLUSION:
Islet microvascular endothelial cells were impaired in type 1 diabetic mice .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2015
Type:
Article
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