Diagnostic sensitivity and specificity of combined detection of serum levels of OPN,MG7 -Ag,TPS for gastric cancer / 中国基层医药

ABSTRACT

Objective To explore the combined detection of serum osteopontin(OPN),gastric cancer associ-ated antigen(MG7 -Ag)and tissue polypeptide specific antigen(TPS)for the clinical value of diagnosis of gastric cancer.Methods Enzyme linked immunosorbent test(ELISA)was used to detect serum levels of OPN,MG7 -Ag and TPS of 60 cases of gastric cancer patients,gastric benign lesion group 20 cases were randomly selected at the same time,the group of 24 cases of precancerous lesions and 40 healthy people were also selected as control study.Results Gastric cancer group′s serum levels of OPN,MG7 -Ag and TPS were significantly higher than those of gastric benign lesions,the precancerous lesion group and healthy control group(F =50.993,62.50,41.396,all P <0.01 ).The single detection sensitivity were 71.7%,80.0% and 67.3% respectively,three joint detection sensitivity was 91.7%.Conclusion Combined detection of serum OPN,MG7 -Ag and TPS can improve the sensitivity of diagnosis of gastric cancer,and has higher diagnosis significance in the diagnosis of gastric cancer.