The regulatory mechanisms of P-glycoprotein in leukemia of multi-drug resistance / 国际儿科学杂志

ABSTRACT

Multidrug resistance (MDR)has been a main reason for the failure of leukemia chemotherapy.The generation of MDR in leukemia is directly related to the transportation of drug efflux of P-glycoprotein (P-gp)on cell membrane surface.Many signaling pathways such as MAPK、NF-κB、Hedgehog、Wnt/β-catenin、 and PI3K/Akt involves in regulating of P-gp expression.Meanwhile, regulation factors including Stats、 microR-NA、TRAIL and HDACs are closely related to the P-gp expression.This review briefly discusses the progress of the regulatory mechanisms of P-gp in MDR of leukemia.