The comparison of clinical improvement effect of lamotrigine and sodium valproate on tardive epilepsy after traumatic brain injury / 中国基层医药

ABSTRACT

Objective To investigate the comparison of clinical improvement effect of lamotrigine and sodi-um valproate on treatment of tardive epilepsy after traumatic brain injury.Methods According to SAS randomly gen-erated random number,the 120 patients with tardive epilepsy after traumatic brain injury in our hospital were randomly divided into lamotrigine group and sodium valproate group,with 60 cases in each group.Lamotrigine group was given lamotrigine for treatment,while the sodium valproate group was given sodium valproate.The clinical improvement effect,the quality of life and the adverse reactions were compared between the two groups.Results After treatment, the total rate of clinical improvement effect in lamotrigine group was 95.00%,which was higher than that in the sodium valproate group(78.33%),and it was statistically significant(χ2 =4.123,P <0.05).The quality of life in the lam-otrigine group was (62.9 ±22.2),which was significantly higher than sodium valproate group(50.6 ±21.7),the difference was statistically significant(t =2.728,P <0.05).The rate of adverse reactions in lamotrigine group was 23.33%,significantly lower than sodium valproate group(73.33%),it was statistically significant(χ2 =4.297,P <0.05).Conclusion Comparison with sodium valproate,patients with tardive epilepsy after traumatic brain injury who were given lamotrigine can effectively improve clinical effect,safety and reduce the rates of adverse reactions.Eventually, treatment with lamotrigine can improve the life quality of patients,which is worth further clinical application.