"Train of Four" Response to Intravenous Suceinylcholine Chloride in Rabbits / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 134-139, 1979.
Article
in Korean
| WPRIM
| ID: wpr-60315
ABSTRACT
The history of muscle relaxants is fascinating, and their use for clinical applications has been accepted. Depolarizing drugs can produce a non-depolarizing type of neuromuscular block. Decamethonium produces a nondepolarizing block in the isolated rabbit lumbrical muscle. Electromyographic studies of the hand muscles in man have demonstrated that a dual block will be produced with doses of succinylcholine varying from 500 to 1,500 mg (initially a delpolarizing block and subsequently a non-depolarizing block exists). The common peroneal nerve in the rabbit knee was stimulated by a "train of four" method (Ali et al) repeated intermittently. The muscle response with the "train of four" method to intravenous succinylcholine chloride (1 mg/kg) in the rabbit was recorded and analysed after a single injection and repeated intravenous injections of succinylcholine chloride 1 mg/kg. Result were as follows 1) Time after the "train of four" to depression of muscle twiteh of 25, 50, 75 & 100% was 128. 2, 135. 3, 142. 8 and 159 seconds respectively. 2) Recovery index of a single intravenous injection of succinylcholine chloride 1 mg/kg was observed as 3 minutes and 14 seconds. 3) A depolarizing form of "train of four" response to the first succinylcholine chloride injection 1 mg/kg was observed and, a non-depolarizing form of "train of four" response to the second dose of succinylcholine chloride 1 mg/kg was observed definitely.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peroneal Nerve
/
Succinylcholine
/
Neuromuscular Blockade
/
Depression
/
Hand
/
Injections, Intravenous
/
Knee
/
Methods
/
Muscles
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1979
Type:
Article
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