Clinical efficacy of Changyunning granula in treatment of ulcerative colitis / 中国生化药物杂志

ABSTRACT

Objective To observe clinical efficacy of Changyunning granula in treatment ofulcerative colitis.Methods 90 cases from March 2014 to August 2015 were randomly divided into observation group and control group of 45 patients in control group received conventional Western medicine treatment, observation group received more Granule intestinal treatment, patients were followed up and recorded Ig and C3 change the situation serum TNF-αand IL-8 changes, colonoscopy curative effect.Results The study group patients IgA, IgG, IgM, C3, respectively (3.65 ±0.48,13.41 ±2.36, 1.98 ±0.39,1.15 ±0.32)g/L, were better than control group (3.78 ±0.39,15.69 ±2.41, 2.45 ±0.36,1.63 ±0.29) g/L, and the difference was statistically significant (P<0.05).After observation group patients serum TNF-αand IL-8 were (26.9 ±6.9,12.5 ±3.8) ng/L, than control group (37.5 ±7.4,27.3 ±6.8)ng/L, and the difference was significant (P<0.05).Clinical observation group after treatment colonoscopy was 93.30%, better than control group, 68.89%, and the difference was statistically significant (P<0.05).Conclusion The clinical effect of intestinal Granule more precise treatment of ulcerative colitis, compared with conventional Western medicine has no significant side effects, it is worthy of further research and application.