Clinical curative effect of pregabalin combined with oxycodone hydrochloride controlled-release tablets on patients with postherpetic neuralgia / 中国生化药物杂志

ABSTRACT

Objective To observe clinical curative effect of pregabalin combined with oxycodone hydrochloride controlled-release tablets on patients with postherpetic neuralgia(PHN).Methods 84 patients with PHN were randomly divided into observation group (n=42 cases) and control group ( n=42 cases); control group was given oxycodone hydrochloride controlled-release tablets, observation group received pregabalin combined with oxycodone hydrochloride controlled-release tablets treatment; NRS, dermatology life quality index (DLQI), Pittsburgh sleep quality score (PSQI) and SAS score were recoded before and after 1,2,4 weeks treatment; 24 h duration of pain, 24 h total sleep time , pain-relief effectiveness and adverse reactions of two group were compared.Results NRS, DLQI, PSQI and SAS score of two groups after 1,2,4 weeks treatment was lower than before treatment (P<0.05), all the scores of observation group were lower than control group (P <0.05); 24 h duration of pain of observation group was obviously less than control group ( P <0.05 ) , 24 h total sleep time was longer than control group ( P <0.05 ); dose of oxycodone hydrochloride controlled-release tablets in observation group was lower than control group ( P <0.05 ); pain relief effectiveness of observation group was obviously higher than that of control group (P<0.05); adverse reactions of observation group such as dry mouth, dizziness was higher than control group (P<0.05), the rest of the adverse reactions in two groups had no significant statistical difference.Conclusions Treatment of pregabalin combined with oxycodone hydrochloride controlled-release tablets are both effective and safe significantly, and can obviously improve the patient’ s pain symptoms, improve quality of life, preferable satisfactory comprehensive curative effect.