Extraction Process Optimization of Total Flavonoids from Chloranthus Japonicus sieb by Box-Behnken Re-sponse Surface Methodology / 中国药师
China Pharmacist
;
(12): 440-442,452, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-603338
ABSTRACT
Objective:
To optimize the extraction process of total flavonoids from Chloranthus japonicus sieb by Box-Behnken re-sponse surface methodology.Methods:
The independent variables were the ethanol concentration ( X1 ) , liquid-solid ratio ( X2 ) and extraction time ( X3 ) , the dependent variable was the extraction amount of total flavonoids ( Y) , and the extraction process was opti-mized by Box-Behnken response surface methodology.Results:
The results showed that the optimal extraction conditions for total fla-vonoids from Chloranthus japonicus sieb were as follows the ethanol concentration was 54. 8%, the liquid-solid ratio was 13. 6, and the extraction time was 2. 0 h. The verified extraction process parameters of three batches showed that the relative error between the ex-perimental values and those predicted from the regression model was -2. 34%.Conclusion:
The optimal extraction process parameters are simple and more convenient with higher precision for the extraction of total flavonoids from Chloranthus japonicus sieb.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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