Value of combined detection of serum CEA,CA199 and CRP in diagnosis and prognosis of colorectal cancer / 国际检验医学杂志

ABSTRACT

Objective To explore the value of the combined detection of serum CEA ,CA199 and CRP in the diagnosis and prog‐nosis of colorectal cancer .Methods Totally 150 patients with colorectal cancer treated in our hospital during 2012‐2014 were se‐lected as the observation subjects ,including 97 cases of histopathologically diagnosed of colorectal cancer without metastasis verified by the assisted examinations as the non‐metastatic group and 53 cases of metastasis verified by the assisted examinations as the me‐tastatic group ;at the sametime ,80 individuals undergoing the physical examination were taken as the control group .Then the levels of serum CEA ,CA199 and whole blood CRP level before surgery and after operation combined with 4 courses of chemotherapy or radiotherapy were compared between the observation group and the control group ,and between the non‐metastatic group and meta‐static group .Results The levels of serum CEA ,CA199 and whole blood CRP before treatment in the observation group were sig‐nificantly higher than those in the control group ,there was statistically significant difference between two groups (P<0 .01) ,more‐over the level of each indicator in the metastatic group of the observation group was higher than that in the non‐metastatic group , the difference between two groups was statistically significant (P<0 .01);compared before treatment ,the levels of serum CEA , CA199 and whole blood CRP after treatment in the observation group were decreased ,the differences between two groups were sta‐tistically significant (P<0 .01);moreover the sensitivity of the combined detection of CEA ,CA199 ,CRP was significantly higher than that of single indicator detection ,the difference was statistically significant (P<0 .01) .Conclusion The combined detection of serum CEA ,CA199 and whole blood CRP is of great importance for the diagnosis and prognosis of colorectal cancer ,which is con‐ducive to the early diagnosis and prognosis evaluation of colorectal cancer .