Therapeutic effect of ATP-sensitive potassium channel opener nicorandil combined with metformin in early T2DN / 重庆医学

ABSTRACT

Objective To observe the therapeutic effect of ATP sensitive potassium channel opening agent nicorandil com‐bined with classical treatment drug metformin for treating type 2 diabetes nephropathy (T2DN ) .Methods Thirty patients with T2DN were selected and divided into the control group(14 cases) and the experimental group(16 cases) .The control group was giv‐en metformin 0 .25 g ,3 times daily for 26 consecutive weeks .The experiment group was given the same dose of metformin and nic‐orandil 5 mg ,3 times daily for 26 weeks .The fasting blood glucose ,total cholesterol ,triglycerides ,low‐density lipoprotein(LDL) , high density lipoprotein(HDL) ,blood urea nitrogen ,serum creatinine ,urine albumin ,IL‐6 and MMP‐9 levels before and after treat‐ment were measured in both groups .Results There was no statistically significant difference in fasting blood glucose level after treatment between the control group and the experimental group(P>0 .05);the LDL level after treatment in the experiment group was significantly lower than that in the control group with statistical difference(P<0 .05);blood urea nitrogen ,serum creatinine and urine albumin levels after treatment in the experimental group were significantly lower than those in the control group with sta‐tistical difference(P<0 .05);the levels of serum IL‐6 and MMP‐9 after treatment in the experiment group were significantly lower than those in the control group with statistical difference(P<0 .05) .Conclusion Metformin combined with nicorandil could delay the progression of T2DN .