Establishment of Determination Method for Benzoic in Ibuprofen Suspension / 中国药师
China Pharmacist
;
(12): 382-383,384, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-603456
ABSTRACT
Objective:
To establish a method to determine benzoic in ibuprofen suspension.Methods:
The determination of ben-zoic was performed on a Kromasil C18 (250 mm × 4. 6 mm, 5 μm) column with the mobile phase consisting of 0. 05 mol·L-1 monopo-tassium phosphate and acetonitrile (72 ∶28). The detection wavelength was 235 nm and the column temperature was 30℃. The injec-tion volume was 10μl.Results:
The limit of detection was 3. 57 ng and benzoic had a good linear relationship within the range of 12. 5-200. 0 μg·ml-1(r=0. 999 9). The solution was stable in 24 hours. The average recovery was 98. 42% and RSD was 0. 98% (n=9) .Conclusion:
The method is simple, repeatable and accurate, and can be used for the determination of benzoic in ibuprofen sus-pension.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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