Study on Varieties and Contents of Related Substances in Cefonicid Sodium by HPLC and MS / 中国药师
China Pharmacist
;
(12): 274-276,286, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-603460
ABSTRACT
Objective:
To study the varieties and contents of related substances in cefalotin sodium by HPLC and MS.Methods:
The quantitative determination of impurity spectra was carried out using self-contrast method, and UPLC-MS was used to preliminarily i-dentify the variety of impurities.Results:
Through the study on the ascription and content of the related substances, there were 6 sub-stances existing in cefalotin sodium, and through the structure analysis, the 6 substances showed antibiotic action and toxicity. Conclu-sionThe method is simple, stable and repeatable, which can be used for the determination of cefalothin sodium and related sub-stances.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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