Therapeutic effect of ellagic acid on Candida albicans infect mice models and its antifungal activity in vitro / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 399-402,403, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-603572
ABSTRACT
Aim To investigate the inhibitory effect of ellagic acid( EA) on fungal strains both in vitro and in vivo. Methods The minimal inhibitory concentration ( MIC ) was determined by the NCCLS ( M27-A2 ) standard method in vitro. The therapeutic action was studied using a Candida albicans infect mice model, the survival rate and the content of SOD, MDA in ser-um were measured, and the pathological changes of liver were observed under light microscope after HE staining. Results EA was active against three Candida strains, with MICs between 25. 0 and 75. 0 mg·L-1 . The most sensitive Candida species was C. albicans ( MIC=25. 0 mg·L-1 ) . It was inactive against Can-dida glabrata. An in vivo test demonstrated that intrap-eritoneal injection of EA(40 and 80 mg·kg-1 ) signif-icantly enhanced the pathological changes of liver, im-proved the symptom, increased the weight and the SOD activity, and decreased the MDA activity in a mice in-fection model of C. albicans. Conclusion Ellagic acid has the potential to be developed as a natural antifungal agent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2016
Type:
Article
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