Clinical observation of methylprednisolone in the treatment of chidren with severe Mycoplasma pneumoniae pneumonia / 中国基层医药

ABSTRACT

Objective To observe the clinical efficacy of methylprednisolone in the treatment of chidren with severe Mycoplasma pneumoniae pneumonia(MPP).Methods 100 children with severe MPP were divided into con-trol group and treatment group.The control group was given to macrocyclic lactone antibiotics,symptomatic and sup-portive and other conventional treatment.The treatment group was given to Methylprednisolone dose for 2mg·kg -1 ·d -1 ×5d at the base of the control group.The clinical manifestations,such as the time of reducing cough,the tem-perature dropped to normal time,pulmonary rales disappeared time,affection absorption time,as well as length of the stay were observed.Results The time of reducing cough,temperature dropped to normal time,pulmonary rales disap-peared time and the affection absorption time of the treatment group were (5.46 ±2.03)days,(3.35 ±1.79)days, (7.08 ±2.56)days,(7.89 ±1.44)days,(10.15 ±2.03)days respectively,which of the control group were (4.23 ± 1.59)days,(5.00 ±2.30)days,(9.07 ±1.9)days,(9.23 ±1.64)days,(12.76 ±2.03)days respectively.The tem-perature dropped to normal time,pulmonary rales disappeared time and the affection absorption time of the treatment group were shorter than the control group(all P 0.05).There was significant difference in cure rate between the two groups(χ2 =5.488, P <0.05).Conclusion The efficacy of methylprednisolone therapy for children with grave Mycoplasma pneumoniae pneumonia(MPP)is affirmation,worthy of clinical application.