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Correlation between epidermal growth factor receptor gene mutations and CT signs in lung adenocarcinoma / 国际生物医学工程杂志
International Journal of Biomedical Engineering ; (6): 20-23,31, 2016.
Article in Chinese | WPRIM | ID: wpr-603738
ABSTRACT
Objective To explore the correlation between epidermal growth factor receptor (EGFR) gene mutations and computed tomography (CT) characteristics in lung adenocarcinoma.Methods Chest CT scan results of 200 postoperative lung adenocarcinoma patients were retrospectively studied,the EGFR gene mutations detection results were statistically analyzed,and the correlation between EGFR gene mutations status and CT characteristics was investigated.Results Single factor analysis results showed that non smoking,female patients,air bronchogram sign and small tumor diameter were significantly associated with EGFR gene mutations (P<0.05),and the incidence of GGO in the EGFR gene mutation group was higher than that in the wild group,but no statistical significance was found (P>0.05),while other clinical and CT signs,such as age,lobulation,spicule,calcification,cavity and pleural indentation were not associated with EGFR gene mutations (P>0.05).Logistics regression analysis results showed that non smoking and air bronchogram sign were significantly associated with EGFR gene mutations (P<0.05),but gender and tumor size were not associated with EGFR gene mutations(P>0.05).Conclusions Non smoking and air bronchogram sign may be used as predictive factors for EGFR gene mutations in lung adenocarcinoma.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Prognostic study Language: Chinese Journal: International Journal of Biomedical Engineering Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Prognostic study Language: Chinese Journal: International Journal of Biomedical Engineering Year: 2016 Type: Article