Determination of Zolpidemtartrate in Plasma by SPE-HPLC / 中国药师
China Pharmacist
;
(12): 788-789,790, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-603813
ABSTRACT
Objective:
To establish a method for the determination of zolpidemtartrate in human plasma by SPE-HPLC.Methods:
The samples were extracted by solid phase with a Hypersil BDS C18 column and determined by an internal standard method. The mobile phase was methanolacetonitrilewater (45 ∶45 ∶110), the flow rate was 1. 0 ml·min-1, the column temperature was 35℃, and the detection wavelength was 254nm.Results:
The linear relationship of zolpidemtartrate was within the range of 0. 511 5-4. 092 0 μg· ml-1 . The relative recovery was greater than 90%. The intra-and inter-day RSDs were all less than 10%.Conclusion:
The method is quite simple, quick and accurate with little interference, which is suitable for the clinical determination of zolpidemtartrate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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