The effects of human papilloma infection status on the DNA ploidy of cervical epithelial cells in Uygur and Han women / 重庆医学

ABSTRACT

Objective To explore the effects of human papilloma(HPV) infection status on the DNA ploidy of cervical epi-thelial cells in Uygur and Han women .Methods Totally 348 women collected who initially received treatment in Tumor Hospital Affiliated to Xinjiang Medical University from July 2012 to June 2014 ,including 181 cases of Uygur and 167 cases of Han women . HPV genotyping was dased on cytology specimens from thin layer of liquid ,and DNA ploidy analyze [DNA index(DI) and S phase cells ratio(SPF)] was conducted by using flow cytometry .All the patients were divided into negative infection group ,non high-risk infection group ,single high-risk HPV infection group and mixed high-risk HPV infection group according to HPV gene type .Re-sults There were statistically significance between Uygur and Han women of DI and SPF in the single high-risk HPV infection group(P= 0 .033 ,P< 0 .01) ,it also present the same trend in mixed high-risk HPV infection group(P = 0 .031 ,P< 0 .01) .It was 19 .783 times and 59 .231 times to appear DNA aneuploid in single high-risk HPV infection and mixed high-risk HPV infection compared to the HPV negative infection group in Uygur women .It was 11 .190 times and 22 .125 times in Han women . Conclusion Single high-risk type HPV infection and mixed high-risk HPV infection had different impact on cervical lesions be-tween Han and Uygur women .It was necessary to respectively study the correlation between cervical lesions and HPV infection for each ethnic groups .