Transarterial chemotherapy embolization combined with high intensity focused ultrasound for treating elderly patients with primary liver cancer / 重庆医学

ABSTRACT

Objective To evaluate clinical therapeutic efficacy of transarterial chemotherapy embolization (TACE) combined with high intensity focused ultrasound (HIFU ) compared with single TACE for treating elder patients ( ≥ 60 years old) with pri-mary liver cancer .Methods Clinical data of 72 elderly patients with primary liver cancer in the Second Affiliated Hospital of Chongqing Medical University were retrospectively analyzed .They were divided into TACE combined with HIFU group (combina-tion group :n= 36) and TACE group (TACE group :n= 36) according to the treatment .Compared tumor shrunk ,the change of AFP value and liver function ,median survival time ,1 year ,2 years ,3 year survival rates in two groups .Results The degree of tumor shrunk in combination group were more significant than that of TACE group (P< 0 .05) ,meanwhile ,AFP value decreased more in combination group (P< 0 .05) .Median survival time in combination and TACE group ,the 1 year ,2 years ,3 year survival rates were (32 .0 ± 6 .9) months ,83 .1% ,57 .3% ,42 .6% and (21 .0 ± 6 .3) months ,62 .9% ,41 .4% ,22 .3% respectively ,as compared with the TACE group ,the combination group had a higher survival rate (P< 0 .05) .There were no severe complications in both groups .Con-clusion The treatment of TACE combined with HIFU is effective and safe for treating elder patients with primary liver cancer and can make more clinical benefits compared with single TACE .