Synthesis of isavuconazonium sulfate:research advances / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 436-440,444, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-604084
ABSTRACT
Isavuconazole is a broad-spectrum triazole antifungal agent,which is administered as a water-soluble prodrug-isa?vuconazonium sulfate. Recently,its oral and intravenous formulations are available. Isavuconazole inhibits fungal cytochrome P45014DM,thus interferes with the biological function of cell wall formation and plays the antifungal role. In this paper ,we summa?rize the synthetic methods of isavuconazole ,water-soluble segments of side chain and isavuconazonium sulfate and evaluate their advantages and disadvantages,which lays a foundation for isavuconazonium sulfate technology development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2016
Type:
Article
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