Spirit Behavioral Changes of Mental Disorders Caused by Traumatic Brain Injury in Rats / 中国医科大学学报

ABSTRACT

Objective To set up traumatic brain injury(TBI)in rats by the improved device of FEENEY ’s weight dropping model and to ex?plore the spirit behavioral changes of mental disorders caused by TBI. Methods SD rats were randomly divided into normal control group(normal group,n=10),traumatic brain injury group(TBI group,n=10)and sham group(n=10). The improved device of FEENEY’s method was ad?opted to establish rat TBI model. For the following 15 days after TBI,open?field(OF)and forced swimming(FS)tests were carried out and the be?havior of the TBI rats within 5 minutes were recorded,the behavioral indexes,such as distance moved total(DMT),velocity mean(VM)and immo?bility time total(ITT),were analyzed. With above experiments,rats' fear response to environment,high alertness and anxiety and depression be?havior were evaluated. Results DMT and VM of TBI group rats(1 228.10±204.97 cm,4.09±0.68 cm/s)were significantly lower than those of the normal group(2 022.32±280.92 cm,7.28±1.80 cm/s)or sham group(1 660.01±332.09 cm,5.53±1.10 cm/s)(P<0.05).The ITT of TBI group (149.88±27.36 s,P<0.05)was longer than that of the normal group(106.10±29.03 s)or sham group(120.55±22.31 s)significantly(P<0.05). Conclusion TBI leads to rats' abnormal emotional and behavioral response.