Correlation of liver cancer ultrasound blood flow characteristics and MVD and VEGF / 中国医学装备

ABSTRACT

Objective:To investigate the characteristics of color Doppler ultrasound of liver cancer blood test, and explore the microvessel density(MVD) and vascular endothelial growth factor(VEGF) relevance.Methods: 60 cases of primary liver cancer patients confirmed pathologically were selected. All the patients were underwent color Doppler ultrasound examination before the surgical resection. The signal of tumor blood flow was recorded from color Doppler flow imaging(CDFI), and the blood flow was graded. Simultaneously, vascular resistance index(RI) and relative perfusion rate were detected. The tumor tissue biopsy was taken from the postoperative patients and tumor tissue MVD and VEGF were detected by immunohistochemical techniques, in order to observe the relationship between blood flow characteristics and tumor tissue MVD and VEGF expression in liver cancer before intraoperative ultrasound.Results:With the increasing flow grade of liver cancer, the tumor tissue and positive expression rate of VEGF were significantly higher than MVD expression. The difference of VEGF expression and MVD between the different flow grade were significantly(x2=11.673,P0.05).Conclusion: Color Doppler ultrasonography which is a non-invasive examination is to detect the hemodynamic characteristics of hepatocellular carcinoma, combined with VEGF and MVD. It can give effective evaluation to the state of liver cancer angiogenesis and provide evidence to the diagnosis, treatment and prognosis of liver cancer.