Influence of Bufalin on the Growth and Proliferation of Human Glioma Cell Line U251 / 中国药师
China Pharmacist
;
(12): 825-827,828, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-604252
ABSTRACT
Objective:
To explore the effects of Bufalin on the growth and proliferation of human glioma cells U251.Methods:
Methyl thiazolyl tetrazolium(MTT)assay was used to detect the effect of Bufalin on the proliferation of human glioma cells U251. An in-verted microscope was used to observe the changes of cell number,morphology and activity. AnnexinV/ PI was used to measure the in-duction of cell apoptosis caused by Bufalin.Results:
Bufalin at different concentrations(0. 001 - 10. 0μmol·L - 1 )inhibited the pro-liferation of U251 cells in a dose and time-dependent manner. Compared with that of the control group,the apoptosis rate of Bufalin group was increased significantly(P < 0. 01).Conclusion:
Bufalin can inhibit the growth and proliferation of U251 cells in a dose and time-dependent manner,and induce the apoptosis of U251 cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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