Base Screening for Gastrodin Nasal in Situ Gel / 中国药师
China Pharmacist
;
(12): 1385-1386,1404, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-604373
ABSTRACT
Objective:
To screen the best base for gastrodin nasal in situ gel ( ISG) to lay foundation for the development of gastrodin new preparation .Methods:
Two bases were chosen , one was the combination of N-trimethyl chitosan ( TMC) , polyethylene glycol 4000 (PEG4000) and glycerophosphate (GP), and another was the combination of TMC, poloxamer 407 (P407), poloxamer 188 (P188) and carbomer.With the nasal cavity temperature of 35℃as the test temperature, the gelling time of the two bases was determined to screen the optimal ratio.Furthermore, gastrodin was added into the two bases , and the gelling time was determined to choose the suitable base for the drug.Results:
The base of TMC-PEG4000-GP couldn’t gel in the nasal cavity temperature when combined with gastrodin , while the base of TMC-P407-P188-carbomer could gel quickly when combined with gastrodin .Conclusion:
TMC-P407-P188-carbomer can be used as the base for gastrodin nasal in situ gel .
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Screening study
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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