Mechanisms of imatinib mesylate induced apoptosis of primary T cells / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 1268-1271,1275, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-604385
ABSTRACT
Objective:
To investigate mechanism of imatinib mesylate induced apoptosis of primary CD3+T cells.Methods:
The CD3+T cells were stimulated by 0-100 nmol/L imatinib for 24 h,cell apoptosis was detected by flow cytometry;Caspase-3,Caspase-8, A20 and NF-κB expression levels were detected by Real-time quantitative PCR and Western blot.Results:
IM significantly increased apoptosis of T cell;Caspase-3 and A20 gene expression levels were upregulated and NF-κB expression level was downregulated both in gene and protein levels.Conclusion:
IM increased apoptosis of T cell by upregulating A20 expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2016
Type:
Article
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