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Mechanisms of imatinib mesylate induced apoptosis of primary T cells / 中国免疫学杂志
Chinese Journal of Immunology ; (12): 1268-1271,1275, 2016.
Article in Chinese | WPRIM | ID: wpr-604385
ABSTRACT

Objective:

To investigate mechanism of imatinib mesylate induced apoptosis of primary CD3+T cells.

Methods:

The CD3+T cells were stimulated by 0-100 nmol/L imatinib for 24 h,cell apoptosis was detected by flow cytometry;Caspase-3,Caspase-8, A20 and NF-κB expression levels were detected by Real-time quantitative PCR and Western blot.

Results:

IM significantly increased apoptosis of T cell;Caspase-3 and A20 gene expression levels were upregulated and NF-κB expression level was downregulated both in gene and protein levels.

Conclusion:

IM increased apoptosis of T cell by upregulating A20 expression.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Immunology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Immunology Year: 2016 Type: Article