Silent mating-type information regulator 2 homolog 1 (SIRT1) in Alzheimer’ s disease:an update on potential mechanisms / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 1041-1043,1044, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-604467
ABSTRACT
Alzheimer ’ s disease ( AD ) is characterized by pro-gressive loss of memory and other cognitive functions .With re-cent discoveries , activation of silent mating-type information reg-ulator 2 homolog 1 ( SIRT1 ) could attenuate the cognitive dys-function of AD via reducing amyloid-βaggregation and tau pro-tein phosphorylation , inhibiting inflammatory reaction , and regu-lating synaptic plasticity .This review aims to highlight the in-volvement of these new discoveries of SIRT 1, and Akt/protein kinase B(PKB) signaling pathways, for their potential therapeu-tic effect against AD .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2016
Type:
Article
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