Kinesin Spindle Protein Inhibition in Translational Research
Journal of Lipid and Atherosclerosis
;
: 63-78, 2014.
Article
in English
| WPRIM
| ID: wpr-60467
ABSTRACT
The kinesin superfamily is a class of motor proteins moving along microtubule filaments and playing essential roles in mitosis of eukaryotic cells. In the cancer biology, mitotic activity is an essential factor for development and metastasis of various cancers. Therefore, the inhibition of kinesin activity is suggested as an alternative cancer therapy. Accumulated clinical evidences have proved the potency of kinesin inhibitors in cancer treatments. In this review, we provided an overview of kinesins that play a critical role in the pathophysiology of various cancers and described the beneficial vs. side effects of their inhibitors that have been tested in both basic science and clinical studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biology
/
Kinesins
/
Eukaryotic Cells
/
Translational Research, Biomedical
/
Microtubules
/
Mitosis
/
Neoplasm Metastasis
Language:
English
Journal:
Journal of Lipid and Atherosclerosis
Year:
2014
Type:
Article
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