Effect of Fluvastatin on Serum vWF and D-D Levels and Heart Function of Patients with Chronic Heart Failure / 中国药房
China Pharmacy
;
(12): 2925-2926,2927, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-605087
ABSTRACT
OBJECTIVE:
To study the effect of fluvastatin on plasma von willebrand factor (vWF),D-dimer(D-D)level and heart function in patients with chronic heart failure(CHF).METHODS:
78 patients with CHF were randomly divided into control group and test group. Control group was given conventional treatment,including cardiac glycoside drugs,diuretics,angiotensin converting enzyme inhibitors or angiotensin receptor blockers andβ-receptor blockers,etc. On this basis,test group was given Fluv-astatin capsules 40 mg,administrated at draught after dinner. The course for both was 28 d. The clinic data was observed,includ-ing left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),vWF,D-D levels before and after treatment and incidence of adverse reactions.RESULTS:
After treatment,the LVEF level in 2 groups was significantly higher than before,and test group was higher than control group;LVEDD,vWF and D-D level were significantly lower than before,and test group was lower than control group,with significant differences(P<0.05). There were no obvious adverse reactions during treat-ment.CONCLUSIONS:
Based on the conventional treatment,fluvastatin can significantly improve the coagulation function in pa-tients with CHF,with good safety.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Type:
Article
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