Clinical Observation of Minocycline Hydrochloride Combined with Tinidazole in the Treatment of Chronic Periodontis / 中国药房

ABSTRACT

OBJECTIVE:To observe the efficacy and safety of minocycline hydrochloride combined with tinidazole in the treat-ment of chronic periodontitis. METHODS:100 patients with chronic periodontitis were randomly divided into observation group 1, observation group 2,observation group 3 and control group. Patients in control group were given full-mouth dental scalers and sub-gingival clean scraping,then 0.9% Sodium chloride injection and 3% hydrogen peroxide were used to alternately wash periodontal pocket bottom. Based on the treatment,observation group 1 was injected Minocycline hydrochloride ointment to periodontal pocket bottom until slight overflow after saliva isolation and desiccation,once a week;observation group 2 was given Tinidazole buccal tablet 1 tablet in the buccal middle gingival surface,twice a day,observation group 3 was given Minocycline hydrochloride oint-ment+Tinidazole buccal tablets(the usage and dosage was the same with above-mentioned 2 groups). The treatment course was 4 weeks. The clinical efficacy,PLI,PAL,PPD,MD,GI before and after treatment and incidence of adverse reactions were observed. RESULTS:The total effective rate in observation group 3>observation group 1 and observation group 2>control group(P0.05). After treatment, PLI,PAL,PPD,MD and GI in all groups were significantly lower than before,and observation group 30.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Minocycline hy-drochloride combined with tinidazole has better efficacy than minocycline hydrochloride or tinidazole in the treatment of chronic periodontitis,with good safety.