Clinical Observation of Lisinopril Combined with Losartan Potassium in the Treatment of Chronic Heart Fail-ure / 中国药房

ABSTRACT

OBJECTIVE:To observe the efficacy and safety of lisinopril combined with losartan potassium in the treatment of chronic heart failure (CHF). METHODS:72 patients with CHF were randomly divided into observation group and control group. All patients were given salt restriction,diuretics and other conventional treatment. Based on the treatment,control group was orally treated with lisinopril tablets 10 mg,once a day,the dose was increased to 2 times after 1-2 weeks until the maximum dose of 40 mg,orally,once a day. Based on the treatment of control group,observation group was additionally treated with losartan potassi-um tablets 50 mg,orally,once a day. The efficacy was evaluated,and cardiothoracic ratio,LVEDD,LVESD,LVEF,HR,SBP,DBP and incidence of adverse reactions were observed after 2 months treatment. RESULTS:The total effective rate in observation group was significantly higher than control group(P0.05). CONCLUSIONS:Based on the coventional treatment,lisinopril com-bined with losartan potassium has better efficacy than lisinopril in the treatment of CHF,with good safety.