Content Determination of Paracetamol by the Nonlinear Quantitative Model with Infrared Spectroscopy / 中国药房
China Pharmacy
;
(12): 3850-3851,3852, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-605562
ABSTRACT
OBJECTIVE:
To provide theoretical basis for the detection of paracetamol by infrared spectroscopy.METHODS:
0.002-0.02 g paracetamol was accurately weighed,added into 0.2 g potassium bromide,respectively,fully ground and well mixed, potassium bromide pressing plate method was used for to-be-tested test sample. Using hollow cathode lamp as light,scanning fre-quency was 30 times,resolution was 0.5 cm-1,scan range was 4000-400 cm-1,infrared absorption spectrum was determined and recorded to select the characteristic absorption peaks,then determine the optimized characteristic absorption peaks. Linear and non-linear models were respectively established by using mathematics modeling methods.RESULTS:
1 016 cm-1 absorption peak with weaker absorbance but stronger features was selected for the analysis. According to the model establishing and calculation,the accu-racy of the nonlinear model was much higher than the linear model,r=0.942.CONCLUSIONS:
Nonlinear quantitative model for quantitatively determining the content of paracetamol is feasible,and suitable for the on-destructive and rapid on-line quality control of paracetamol.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
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