The diagnostic value of high density lipoprotein cholesterol, serum albumin and C reactive protein in patients with severe acute pancreatitis / 中国生化药物杂志

ABSTRACT

Objective To investigate the diagnostic value of serum high density lipoprotein cholesterol (HDL-C), serum albumin (SA) and C reactive protein ( CRP) levels combined detection of severe acute pancreatitis.Methods 180 cases of acute pancreatitis were selected from January 2012 to January 2015 in Tianjin fifth central hospital,including 87 severe acute pancreatitis ( SAP) and 93 mild acute pancreatitis ( MAP) , and 100 cases of healthy people were selected as control group.The serum levels of HDL-C, SA and CRP were compared among three groups.Results HDL-C and SA in SAP group and MAP group were significantly lower than control group (P<0.05), the level of CRP was significantly higher than that of control group ( P<0.05); HDL-C, SA levels in SAP group were significantly lower than those of MAP group, the CRP level was significantly higher than that of MAP group (P<0.05).Compared to HDL-C and SA, the sensitivity(89.4%), specificity (95%) and accuracy (92%) of CRP were significantly higher (P<0.05).The sensitivity(93.6%)and specificity (95%) and accuracy (94.3%) of combined detection of three markers were significantly higher than the detection results of the three indexes either,the differences were statistically significant (P <0.05).Conclusion The combined detection of serum HDL-C, SA and CRP levels can effectively improve the early diagnosis rate of SAP, and provide reference for clinical diagnosis.