Effects of Maiqi Jiangtang Pill Combined with Insulin on Related Indicators in Maternal Gestational Diabetes / 中国药房

ABSTRACT

OBJECTIVE:To investigate the effects of Maiqi jiangtang pill combined with insulin on related indicators in mater-nal gestational diabetes. METHODS:135 GDM women were randomly divided into control group (69 cases) and observation group(66 cases). Control group was given diet controlling and exercise therapy,Novolin R insulin biosynthesis and protamine syn-thetic human insulin were injected before meals and bedtime from 4-6 units with the ratio of 4∶2∶3∶1,and decided whether to ad-just the insulin dose based on the blood glucose monitoring results(increase or decrease 2-4 units each times);observation group was additionally given 6 g Maiqi jiangtang pill,4 times a day. The treatment course for both groups was 15 d. Fasting plasma glu-cose(FPG),2 h postprandial glucose(2 h PG),glycated hemoglobin(HbA1c),body mass index(BMI),maternal pregnancy out-comes(preeclampsia,preterm labor,puerperal infection,postpartum hemorrhage,neonatal asphyxia,low-weight children and noc-turnal hypoglycemia)and incidence of adverse reactions in 2 groups were observed. RESULTS:FPG,2 h PG,HbA1c,BMI,pre-eclampsia,preterm labor,low-weight children,neonatal asphyxia and nocturnal hypoglycemia in observation group were signifi-cantly lower than control group,the differences were statistically significant(P0.05). And there were obvious adverse reactions between 2 groups during treatment. CONCLUSIONS:Maiqi jiangtang pill combined with insulin can effectively reduce the blood glucose of GDM women,with good safety.