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Comparative Study of Budesonide and Beclomethasone Assisting with Terbutaline by Atomization Inhala-tion in the Treatment of Acute Pediatric Asthma Attack / 中国药房
China Pharmacy ; (12): 2388-2390,2391, 2016.
Article in Chinese | WPRIM | ID: wpr-605722
Responsible library: WPRO
ABSTRACT

OBJECTIVE:

To compare clinical efficacy and safety of budesonide and beclometasone assisting with terbutaline by atomization inhalation in the treatment of acute pediatric asthma attack.

METHODS:

150 pediatric patients with acute asthma attack were randomly divided into group A and group B,with 75 cases in each group. Both group received symptomatic support treatment as low-flow oxygen inhalation,eliminating phlegm,relieving a cough,dilating bronchus and anti-infection,and atomization inhala-tion of budesonide,1 ml each time,bid. Based on this,group A was given atomization inhalation of budesonide,2 ml each time, bid;group B was given atomization inhalation of beclometasone,2 ml,bid. Treatment course of 2 groups lasted for 7 d. Clini-cal efficacy,asthma control,PEF% and the occurrence of ADR were observed in 2 groups;the time of symptoms and signs dis-appearance and hospitalization time were recorded,and symptoms and signs of children were scored 1 day before treatment and 7 days after treatment.

RESULTS:

During treatment,2 cases and 3 cases were withdraw from the test in group A and group B, respectively. The total effective rates of group A and B were 91.78% and 94.44%,and the rate of asthma control 95.89% and 94.44%,without statistical significance(P>0.05). The time of breathing difficulties disappearance,cough disappearance time, wheezing disappearance time and hospitalization time of group A were separately (2.11 ± 0.54),(3.28 ± 0.93),(4.38 ± 1.05), (5.83±1.29)d;those of B group were separately(2.07±0.52),(3.30±0.96),(4.45±1.08),(5.90±1.33)d,there was no sig-nificant difference between 2 groups(P>0.05). The clinical symptoms and signs score of group A before and after treatment were separately (4.28 ± 0.94) and (0.15 ± 0.04);those of before and after treatment of group B were separately (4.23 ± 0.91) and(0.11±0.03). There was significant difference before and after treatment(P0.05). The PEF% of group A before and after treatment were separately (51.4 ± 9.8)% and (67.2 ± 11.2)%;those of before and after treatment of group B were separately(52.0±7.1)%and(68.3±8.7)%. There was significant difference before and after treatment (P0.05). No obvi-ous ADR was found in 2 groups.

CONCLUSIONS:

Budesonide and beclometasone assisting with terbutaline by atomization inha-lation in the treatment for acute pediatric asthma attack possess the same effects and can efficiently relieve symptoms and signs, increase the rate of asthma control and shorten the rehabilita-tion course with good safety.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2016 Type: Article