Effects of Calcium Ion on the Stability of Total Parenteral Nutrition Solution / 中国药房
China Pharmacy
;
(12): 2339-2341,2342, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-605724
ABSTRACT
OBJECTIVE:
To study the effects of calcium ion(Ca2+)on the stability of total parenteral nutrition(TPN),and to provide reference for clinical use.METHODS:
4 kinds of TPN containing different contents of Ca2+were prepared according to ster-ile operation procedure,and at room temperature,their microbial limit,appearance,pH value,osmotic pressure molar concentra-tion,the number of insoluble particle and emulsion particle size were investigated at 0,2,4,6,8 and 24 h.RESULTS:
Within 24 h,no bacterial colony was found in TPN,and its appearance had no obvious change;pH value of TPN were all higher than 5 at different time points,without statistical significance(P>0.05);osmotic pressure molar concentration of TPN were all within the range of normal human blood(280-310 mOsmol/kg),without statistical significance(P>0.05). As the increase of Ca2+,the num-ber of insoluble particle ≥10 μm in TPN showed increasing tendency,with statistical significance (P0.05). There was statistical significance in emulsion partial size of TPN at different time points(P<0.05).CONCLUSIONS:
Ca2+ can influence the stability of TPN,manifesting as the number of insolu-ble particle ≥10 μm and emulsion partial size increase. To garantee the safety of TPN use in the clinic,the concentration of biva-lent cation in TPN prescrption should be kept in reasonable range,and TPN should be used as soon as possible after preparation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2016
Type:
Article
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