Effects of Single Administration by Different Ways on Drug Accumulation Concentration and Treatment of Tumor Tissue before Surgery / 中国药房

ABSTRACT

OBJECTIVE:To observe the effects of single administration of carboplatin by different ways on drug accumulation concentration and treatment of tumor tissue before surgery. METHODS:60 patients with resectable advanced gastric cancer were randomly divided into intraperitoneal administration group(30 cases)and intravenous administration group(30 cases). All patients received 50 mg/m2 Carboplatin injection,intravenous administration,it stopped 4 weeks after continuous 5 d,repeated 3 times, when the last chemotherapy,intraperitoneal administration group was given 30 mg/m2 Carboplatin injection,adding into 750 ml 0.9% Sodium chloride injection,and placed in 37 ℃ water bath for preheating,taking paracentesis for disposable rapid injection. Intravenous administration group was 30 mg/m2 Carboplatin injection,adding into 750 ml 0.9%Sodium chloride injection,by intra-venous infusion within 30 min. Both groups were administered once for at least 1 week,then surgery was taken after 5 d. The car-boplatin accumulation concentration in 2 groups was determined after 160-180 min and 250-260 min,respectively,and the efficacy in the 5th day and incidence of adverse reactions during treatment were recorded. RESULTS:The total effective rate after 5 d,peri-toneal fluid,portal vein and peripheral blood after 160-180 min,and carboplatin accumulation concentration in cancer tissues,adja-cent normal tissues,peritoneum,omentum and negative lymph node after 250-260 min in intraperitoneal administration group were significantly higher than intravenous administration group,the incidence of adverse reactions was significantly lower than intrave-nous administration group,the differences were statistically significant(P<0.05). CONCLUSIONS:Compared with intravenous in-fusion,intraperitoneal injection of carboplatin before surgery can improve the local accumulation concentration and chemotherapeu-tic effect and reduce incidence of adverse reactions.