Clinical Observation of High-dose Valaciclovir Combined with Acupuncture in the Treatment of Herpes Zoster ZHOU / 中国药房

ABSTRACT

OBJECTIVE:To investigate the clinical efficacy and safety of high-dose valaciclovir combined with acupuncture in the treatment of herpes zoster. METHODS:194 patients with herpes zoster were divided into control group and observation group according to random number table method,with 97 cases in each group. Control group was given acupuncture treatment;observa-tion group was additionally given Valaciclovir hydrochlordide tablet 0.3 g,bid,based on control group. Both group received treat-ment for 10 d. Clinical efficacy and the time of clinical symptoms improvement were observed in 2 groups as well as VAS score and substance P level before and after treatment. The occurrence of postherpetic neuralgia and ADR were also observed in 2 groups. RESULTS:Total effective rate of observation group was 97.9%,which was significantly higher than 90.7% of control group,with statistical significance(P0.05);those of 2 groups were decreased sig-nificantly after treatment,and the observation group was lower than the control group,with statistical significance(P0.05). CONCLUSIONS:High-dose valacyclovir combined with acupuncture can effectively treat herpes zoster,with advantages of analge-sic effect,rapid lesions recovery,low rate of postherpetic neuralgia with good safety.