The Role of Regulatory T Cells in Cancer
Immune Network
; : 209-235, 2009.
Article
in En
| WPRIM
| ID: wpr-60583
Responsible library:
WPRO
ABSTRACT
There has been an explosion of literature focusing on the role of regulatory T (Treg) cells in cancer immunity. It is becoming increasingly clear that Treg cells play an active and significant role in the progression of cancer, and have an important role in suppressing tumor-specific immunity. Thus, there is a clear rationale for developing clinical strategies to diminish their regulatory influences, with the ultimate goal of augmenting antitimor immunity. Therefore, manipulation of Treg cells represent new strategies for cancer treatment. In this Review, I will summarize and review the explosive recent studies demonstrating that Treg cells are increased in patients with malignancies and restoration of antitumor immunity in mice and humans by depletion or reduction of Treg cells. In addition, I will discuss both the prognostic value of Treg cells in tumor progression in tumor-bearing hosts and the rationale for strategies for therapeutic vaccination and immunotherapeutic targeting of Treg cells with drugs and microRNA.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Vaccination
/
T-Lymphocytes, Regulatory
/
MicroRNAs
/
Explosions
/
Immunotherapy
Limits:
Animals
/
Humans
Language:
En
Journal:
Immune Network
Year:
2009
Type:
Article