Roles of liver sinusoidal endothelial cells in liver diseases / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 149-152,153, 2017.
Article
in Zh
| WPRIM
| ID: wpr-606133
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WPRO
ABSTRACT
Liver sinusoidal endothelial cells (LSECs) are the highest proportion of liver non-parenchymal cells with fenestrae structure and high endocytic ability maintaining liver homeostasis and playing an indispensable role in the physiology and patholo-gy of the liver.LSECs are involved in the regulation of patholog-ical process in nonalcoholic fatty liver disease(NAFLD),alco-holic fatty liver(AFL),hepatocellular carcinoma(HCC),liverregeneration and liver fibrosis mainly via antiinflammation,endocytosis,secretion of angiocrine signals and maintaining thequiescence phenotype of HSCs.This review highlights the physiological function of LSECs and the different roles in different pathological conditions,which aims to provide a new perspectivefor the treatment of liver diseases through targeting LSECs.
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Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2017
Type:
Article