Effects of decreasing lipidemia by mappianthus iodoies flavone in SD rats / 重庆医学

ABSTRACT

Objective To explore effect of decreasing blood lipid by mappianthus iodoies flavone in rats model.Methods We selected sixty healthy male SD rats,which were randomly divided into six groupsnormal control group (NC),model control group (MC),simvastatin group positive control group (PC),low dose group of mappianthus iodoies flavonoids (MIF1 group),middle dose group of mappianthus iodoies flavonoids (MIF2 group),high dose group of mappianthus iodoies flavonoids (MIF3 group).After 6 weeks,absolute diet 12 h,the rats of blood samples were drawn from orbit and it was collected to detect serum total cholesterol (TC),serum triglyceride(TG),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C).After 12 weeks,absolute diet 12 h,get blood from heart,serum,centrifugal separation measure serum SOD,MDA content,test the content of T-AOC.Results Mappianthus iodoies flavonoids can decrease the level of TG,TC,LDL-C,MDA and improve HDL-C,SOD and T-AOC in lipid of lipidemia rats.Especially compared with the NC group,the level of TG,TC,LDL-C,MDA in MC group were in creased,and HDL-C,SOD,T-AOC level were decreased in rats fed high fat diet(P＜0.05),meanwhile the levels of TC,TG and LDL C in the treatment groups were decreased,and HDL-C levels were increased(P＜0.05);MIF group,which are compared with MC,the level of TC,TG,LDL-C and MDA weresignificantly decreased and the level of HDL-C,SOD,T-AOCwere increased significantly(P＜0.05).Conclusion Mappianthus iodoies flavone may improve the level of SOD,T-AOC and decrease the level of MDA to decrease lipid.