Expression and Clinical Significance of SETDB1 in Human Ovarian Carcinoma / 医学研究杂志

ABSTRACT

Objective To investigate the expression and clinical significance of SETDB1 in human ovarian carcinoma.Methods 44 ovarian carcinoma tissues and matched tumor-adjacent tissues were collected from January,2010 to December,2012.The mRNA expression of SETDB1 was detected by qRT-PCR,and the protein expression of SETDB1 was detected by immunohistochemistry.The correlation between SETDB1 and clinic pathological features was analyzed by chi-square test,and the Kaplan-Meier survival curves were drawn to describe the prognostic effects of SETDB1 expression.Results The expression of SETDB1 was up-regulated in ovarian carcinoma tissues compared to those matched tumor-adjacent tissues(P ＜ 0.05).Positive expression of SETDB1 was associated with lymphatic metastasis (P ＜ 0.05) and advanced FIGO stage (Ⅲ + Ⅳ,P ＜ 0.05).Both the 3-year overall survival rate and tumor-free survival rate were lower in SETDB1 positive expression group than SETDB1 negative expression group (P ＜ 0.05).Conclusion Positive expression of SETDB1 in human ovarian carcinoma is related to the poor prognosis.SETDB1 has a potential to predict the prognosis for ovarian carcinoma patients.