Establishment of normal reference intervals of plasma and urine neutrophil gelatinase associated lipocalin in children / 国际检验医学杂志

ABSTRACT

Objective To establish normal reference intervals of plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) in children′s hospital.Methods A total of 183 fresh EDTA anticoagulant samples and 125 fresh urine in healthy children were collected from May 2014 to October 2014.According to the CLSI C28-A2 ,the unilateral upper limit 95% was established the normal reference value in different age group.Results There was significant difference in four groups (P<0.05).The normal reference intervals of plasma NGAL in healthy children0 to <7 months;<291.28 μg/L;7 months to <5 years old;<150.87 μg/L;5 years old to <9 years old<127.93 μg/L;9 years old to ≤16 years old<161.74 μg/L;the normal reference intervals of healthy children urine NGAL0 to <7 months<257.31 μg/L;7 months to <5 years old<201.55 μg/L;5years old to <9 years old<197.69 μg/L;9 years old to ≤16 years old<151.46 μg/L.Plasma and urine NGAL results in neonatal group were higher than the other three groups.Conclusion The normal reference intervals of plasma and urine NGAL in children′s hospital is established.this could provide clinical evidence for the diagnosis and treatment of acute renal injury in pediatric patients.