Significance of detection of serum Omentin-1 and MMP 9 level in patients with ischemic stroke complicating multiple sclerosis / 国际检验医学杂志

ABSTRACT

Objective To investigate the significance of serum Omentin-1 and matrix metalloproteinases-9 (MMP 9) level detec-tion in the patients with ischemic stroke complicating multiple sclerosis (MS) .Methods A total of 169 patients with ischemic stroke in our Hospitals from September 2013 to September 2016 were selected as the diseases group and divided into the combined group (n=57 cases) and single disease group (n=112) according to whether complicating DS .Contemporaneous 30 health persons in the physical examination center were chosen as the health group .The enzyme-linked immunosorbent assay (ELISA) was used to detect serum Omentin-1 and MMP-9 levels in all subjects .Then the serum Omentin-1 and MMP-9 levels and neural function were statisti-cally analyzed .Results Serum MMP-9 level and EDSS score in the disease group were significantly higher than those in the healthy group ,the serum Omentin-1 levels of the former was significantly lower than that of the latter ;serum MMP-9 level and expaned disability status Scale(EDSS) score in the combined group were significantly higher than those in the single disease group ,the ser-um Omentin-1 levels of the former was significantly lower than that of the latter ,the difference was statistically significant (P<0 .05);The Pearson correlation analysis results showed that the serum Omentin-1 level was negatively correlated with the EDSS score (r= -0 .724 ,P<0 .05) ,the serum MMP-9 level was positively correlated with the EDSS score (r=0 .763 ,P<0 .05);the Logistic regression analysis results showed that low serum Omentin-1 level ,high MMP-9 level of and high EDSS score were the in-dependent risk factors for ischemic stroke complicating MS (P<0 .05);the ROC curve analysis results showed that serum Omentin-1 level of 180 ng/mL serving as the cutoff value and serum M M P-9 level of 260 ng/mL as the cutoff value ,the sensitivity ,specific , accuracy of their combination for predicting ischemic stroke complicating MS were 94 .74% ,96 .43% and 95 .86% respectively . Conclusion Serum Omentin-1 and MMP-9 levels are related with the occurrence and development of ischemic stroke complicating MS ,are the independent risk factors for the latter occurrence ,moreover can effectively assess the patient′s neurologic disability situ-ation ,their joint detection can effectively assist doctors to assess the patient′s condition change ,and can effectively predict the oc-currence of ischemic stroke complicating MS ,which is worth further clinical promotion .