Expression and Clinical Significance of c-Src in the Epithelial Ovarian Carcinoma / 现代生物医学进展
Progress in Modern Biomedicine
;
(24): 5022-5028, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-606799
ABSTRACT
Objective:
we aim to determine the relationship between Cell sarcoma (c-Src) expression in patients with EOC and the disease phenotype.Methods:
c-Src expression was evaluated using Western blotting analysis in 21 ovarian carcinomas and 4 normal ovarian tissues.Immunohistochemistry was used to evaluate c-Src expression in 134 ovarian carcinomas and 26 normal ovarian tissues.The association between c-Src expression and clinically pathologic characteristics were also assessed in these patients.Results:
Our results indicated elevated c-Src protein in EOCs compared with that in normal tissues.The overexpression of c-Src was significantly associated with aggressive features,such as advanced disease stage,poor histological grade,lymph node metastasis,and tumor recurrence (P<0.05).In addition,the overexpression ofc-Src is significantly associated with EOCs' prognosis.Conclusion:
c-Src overexpression was significantly associated with the malignant biological behavior of tumor,suggesting c-Src as a potential preventive target in these patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Progress in Modern Biomedicine
Year:
2017
Type:
Article
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