Directional differentiation of bone marrow mesenchymal stem cells / 中国组织工程研究

ABSTRACT

BACKGROUND: Bone marrow mesenchymal stem cells is the most promising tissue engineering seed cells because of their strong proliferation and passage ability, multi-directional differentiation potential, as well as no ethical problems and no rejection.OBJECTIVE: To review the recent advances in the directional differentiation of bone marrow mesenchymal stem cells induced by various conditions METHODS: The first author retrieved CNKI, PubMed, Wanfang databases for relevant articles published from January 2001 to September 2016. The keywords were bone marrow mesenchymal stem cells, BMSCs, directional differentiation in Chinese and English, respectively. Literature addressing experimental research and review were selected, and finally 48 articles were included.RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells can be induced in vitro to differentiate into chondrocytes, osteoblasts, adipocytes, and nerve cells by cytokines, chemical drugs, Chinese herbs and extracts, physical stimulation. To establish feasible induction conditions in vitro and improve cell induction efficiency is the basis for the clinical application of bone marrow mesenchymal stem cells.