Hepatitis C Virus Infection in Pregnancy / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 597-603, 2000.
Article
in Korean
| WPRIM
| ID: wpr-60700
ABSTRACT
OBJECTIVE:
Our purpose was to estimate the prevalence of hepatitis C virus seropositivity and define the risk factors for HCV infection in a group of pregnant women and the effect of HCV infection to mother and baby at the time of delivery.METHODS:
From March 1997 to February 1998, 5655 women who delivered over 20 gestational weeks at our hospital were screened for HCV-Antibody(RIA), and the samples of most of HCV-Ab positive cases were analyzed for HCV-RNA by polymerase chain reaction(PCR). We also studied the risk factors for HCV infection, the effect of HCV infection to mothers and neonates at delivery.RESULTS:
Of 5655 mothers 25 (0.44%) were HCV-Ab positive, and 20 of HCV-Ab positive mothers were analyzed for HCV-RNA by PCR. Of 20 HCV-Ab positive mothers 12 cases (60%) were HCV-RNA positive. Risk factors significantly more prevalent among HCV-seropositive patients were a history of habitual intraveneous drug use, a history of smoking, alcohol drinking during pregnancy, having liver cirrhorsis. The proportions who had received a blood transfusion, had a history or ongoing syphilis or were positive for hepatitis B virus surface antigen were not significantly different between seropositive and seronegative women. Liver function test at delivery was abnormal in 4 cases(16%) of HCV-Ab positive group. And the number of abnomal liver function test cases in HCV-Ab negative group were 47(0.83%). This had statistical difference. In neonates at delivery, all 20 neonates of 20 ones having HCV-Ab positive mother were HCV-Ab positive. But only 2 cases of 20 babies were HCV-RNA positive.CONCLUSION:
Mothers who have risk factors such as injecting drug use, smoking, alchohol drinking and liver cirrhorsis, should undergo HCV-Ab testing and quantitative HCV-RNA testing by PCR. More advanced studies about vertical transmission of HCV infection are needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
Blood Transfusion
/
Alcohol Drinking
/
Smoking
/
Syphilis
/
Hepatitis B virus
/
Polymerase Chain Reaction
/
Prevalence
/
Risk Factors
/
Hepatitis C
Type of study:
Etiology study
/
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2000
Type:
Article
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