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Effect of systemic low-level light therapy on early systemic inflammatory response of severe burn rats / 第二军医大学学报
Academic Journal of Second Military Medical University ; (12): 987-992, 2017.
Article in Chinese | WPRIM | ID: wpr-607055
ABSTRACT
Objective To explore the effect of systemic low-level light therapy (LLLT) on early inflammatory response of severe burn rats.Methods Fifty SD rats were randomly divided into control group,burned model group,single short-term LLLT group,single long-term LLLT group and the repeated short-term LLLT group,with 10 rats in each group.After burning the rats in the single short-term LLLT group,the single long-term LLLT group and the repeated short-term LLLT group were treated by low-intensity LED irradiation (640 nm) for 5 min once a day,15 min once a day and 5 min three times a day,respectively.The levels of tumor necrosis factor α (TNF-α),interleukin (IL)-1β and IL-6 and the leukocyte count in caudal vein were determined at 1 day before modeling,immediately after modeling and on the 1st,3rd,7th and 14th day after modeling;and the wound area was measured on the 3rd,7th and 14th day after modeling.The wound healing rate was calculated.Results Compared with the control group,the serum TNF-α levels in the burned model and single short-term LLLT groups were significantly increased on the 1st day after modeling (P<0.05),and the serum TNF-α levels in the single long-term LLLT group on the Pt day and the repeated short-term LLIT group on the 7th day were significantly increased (P<0.05);the serum IL-1β levels were significantly decreased on the 1st day after modeling in all groups (P<0.05),and then gradually recovered with the varied recovery rates;the serum IL-6 levels in the burned model and the repeated short-term LLLT groups were significantly increased on the 1st day after modeling (P<0.05),then decreased;and the decrease of the burned model group was greater than that of the repeated short-term LLLT group.While the serum IL-6 level was increased on the 3rd day in the single short-term LLLT group,then decreased;and the level was significantly increased in the single long-term LLLT group (P<0.05).Leukocyte counts of the burned model and the single long-term LLLT groups were significantly increased on the 1st day after modeling (P<0.05),and it had no significant change in the other groups.The wound healing rate in the single short-term LLLT group,the single long-term LLLT group and the repeated short-term LLLT group was significantly higherthan that in the burned model group (P<0.05).Conclusion Systemic LLLT use can reduce the serum levels of TNF-α,IL-1β and IL-6 and leukocyte count in caudal vein of the severe burning rats and promote wound healing,with the effects varied with different irradiation modes.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Academic Journal of Second Military Medical University Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Academic Journal of Second Military Medical University Year: 2017 Type: Article