Clinical Observation of Breviscapine Combined with Vinpocetine in the Treatment of Acute Cerebral In-farction / 中国药房
China Pharmacy
;
(12): 3678-3681, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-607132
ABSTRACT
OBJECTIVE:
To investigate clinical efficacy and safety of breviscapine combined with vinpocetine in the treatment of acute cerebral infraction.METHODS:
A total of 80 patients with acute cerebral infraction were selected from our hospital during Jan. 2014-Dec. 2015,and then divided into observation group and control group according to random number table,with 40 cases in each group. Control group was given Vinpocetine injection 20 mL+0.9% Sodium chloride injection 250 mL,ivgtt,qd. Observa-tion group was additionally given Breviscapine injection 20 mL+5% Glucose injection 250 mL,ivgtt,qd,at intervals of 2-3 h on the basis of control group. Both groups were treated for 2 weeks. Clinical efficacies as well as serum copeptin,NT-proBNP,albu-min cobalt binding(ACB)value,European stroke scale(ESS)and functional independence measurement(FIM)score before and after treatment were observed in 2 groups,and the occurrence of ADR was recorded.RESULTS:
Total response rate of observation group(90.0%)was significantly higher than that of control group(67.5%),with statistical significance(P0.05). After treatment,serum copeptin and NT-proBNP levels of 2 groups were decreased significantly,while ACB value,ESS and FIM score were increased significantly;the improvement of observation group was significantly better than that of control group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups.CONCLUSIONS:
Breviscapine combined with vinpocetine can improve neurological function of acute cerebral infraction patients and show good therapeutic efficacy with good safety.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2017
Type:
Article
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