Analysis of 309 Antineoplastics-induced ADR Reports in a Tumor Hospital / 中国药房
China Pharmacy
; (12): 3646-3649, 2017.
Article
in Zh
| WPRIM
| ID: wpr-607137
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:To investigate the characteristic and regularity of antineoplastics-induced ADR,and to provide refer-ence for safety use of antineoplastics in clinic. METHODS:In retrospective study,309 cases of antineoplastics-induced ADR col-lected from a special hospital during Jan.-Dec. 2015 were summarized and analyzed statistically. RESULTS:Among 309 ADR cas-es,female (58.25%) was more than male (41.75%). The patients aged more than 40 years old occupied the highest proportion (78.64%). Main route of administration was intravenous dripping(94.82%). There were 225 cases of severe ADR(72.82%). To-tal 268 cases were improved after drug withdrawal or treatment(86.73%). A total of 24 kinds of antineoplastics were involved in 309 ADR cases;most of ADR were induced by docetaxel,followed by cisplatin,cyclophosphamide. Most common organs/system involved in ADR was hemopoietic system (64.24%),main clinical manifestation was myelosuppression. CONCLUSIONS:It is necessary to strengthen ADR monitoring,prevent,discover and treat antineoplastics-induced ADR timely,in order to reduce the harm to the patients and ensure the safety and effectiveness of drug treatment.
Full text:
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Index:
WPRIM
Type of study:
Observational_studies
Language:
Zh
Journal:
China Pharmacy
Year:
2017
Type:
Article